Guiding enterprises toward sustainability requires setting targets and measuring performance across scopes, scales, and timeframes. A plethora of approaches have been engaged with to date, each featuring their own taxonomy, methodology, and metrics. THRIVE is The Holistic Regenerative Integrated Value Enterprise framework which rather than re-invent a new approach, re-integrates what the best available science shows us is necessary and sufficient to guide enterprises onto the trajectory towards thrivable transformations. With information, methods and patterns largely obscured by the vastness of the datasets involved, THRIVE platform leverages information systems, machine learning, and extensive science-based public datasets to develop backcast targets for a prosperous future for all humankind.